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Tuesday, 25 September 2007
Tackle your research with Invitrogen and win a rugby ball!
Monday, 24 September 2007
EBook-Clinical Chemistry: A Laboratory Perspective
- Publisher: F. A. Davis company
- Of Pages:number 582
- Date:publication 2007-01-30
- Rank:sales 240445
- ISBN / ASIN: 0803614985
- EAN: 9780803614987
- Binding: Hardcover
- Manufacturer: F. A. Davis Company
- Studio: F. A. Davis Company
- Download
Ebook Biology in the Laboratory: (3rd edition)
- Publisher: W. H. Freeman
- Of Pages:number 500
- Date:publication 1997-12-15
- Rank:sales 36692
- ISBN / ASIN: 0716731460
- EAN: 9780716731467
- Binding: Paperback
- Manufacturer: W. H. Freeman
- Studio: W. H. Freeman
- Review: Download
Tuesday, 18 September 2007
Transfection Research Award ASCB Annual Meeting, D.C
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Saturday, 15 September 2007
eBook Mathematical Methods in Natural Science
Mathematical Methods in Natural Science
This book provides a general introduction to applied analysis; vector analysis with physical motivation, calculus of variation, Fourier analysis, eigenfunction expansion, distribution, and so forth, including a catalogue of mathematical theories, such as basic analysis, topological spaces, complex function theory, real analysis, and abstract analysis. This book also gives fundamental ideas of applied mathematics to discuss recent developments in nonlinear science, such as mathematical modeling of reinforced random motion of particles, semi-conductor device equation in applied physics, and chemotaxis in biology. Several tools in linear PDE theory, such as fundamental solutions, Perron's method, layer potentials, iteration scheme, are described, as well as systematic descriptions on the recent study of blowup of the solution. Link
eBook Neuroscience and Philosophy: Brain, Mind, and Language
Neuroscience and Philosophy: Brain, Mind, and Language
Publisher: Columbia University Press
Of Pages:number 232
Date:publication 2007-03-15
Rank:sales 24722
ISBN / ASIN: 0231140444
EAN: 9780231140447
Binding: Hardcover
Manufacturer: Columbia University Press
Studio: Columbia University Press
Writing and Presenting in English:The Rosetta Stone of Science
Writing and Presenting in English: The Rosetta Stone of Science
Writing and Presenting in English: The Rosetta Stone of ScienceThe Rosetta Stone of Science is a useful and practical guide to presenting scientific research in the English language. It is written specifically for scientists who would like to improve the effectiveness with which they use the English language and improve their communicative skills in order to become published and develop more confidence in presenting their work at international conferences.
Part 1 of the book covers the style preferred by today's leading journals, discusses how to prepare models for writing research papers, and provides advice for writing abstracts, proposals, and editing. Examples of cover letters are also given. Part 2 discusses the various arts and techniques used by successful presenters at scientific conferences.
The content of the book is presented in a light, simple and informative manner making The Rosetta Stone of Science an entertaining and instructive read. This book will prove invaluable to all scientists, research fellows, post-docs, and graduate students whose first language is not English. Link
Wednesday, 12 September 2007
Principles and Practice of Pharmaceutical Medicine Ebook
Publisher: Wiley
Number Of Pages: 780
Publication Date: 2007-06-15
Sales Rank: 862664
ISBN / ASIN: 0470093137
EAN: 9780470093139
Binding: Hardcover
Manufacturer: Wiley
Studio: Wiley
Book Description:
The long awaited second edition of Principles and Practice of Pharmaceutical Medicine provides an invaluable guide to all areas of drug development and medical aspects of marketing. The title has been extensively revised and expanded to include the latest regulatory and scientific developments. New chapters include:
European Regulations
Ethics of Pharmaceutical Medicine
Licensing and Due Diligence
Pharmacogenomics
Encompassing the entire spectrum of pharmaceutical medicine, it is the most up-to-date international guide currently available.
Review of the first edition:
“This book was a joy to read and a joy to review. All pharmaceutical physicians should have a copy on their bookshelves, all pharmaceutical companies should have copies in their libraries.”
BRITISH ASSOCIATION OF PHARMACEUTICAL PHYSICIANS. Download
New Mycoplasma Elimination Reagent Lonza
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Reports are that 5-35% of all cells in continuous culture are contaminated with mycoplasma. A cell line infection can affect every known process in the cell and can seriously impact the reliability, reproducibility and consistency of results. Additionally, mycoplasma infections can spread easily within the culture environment.
To monitor for such infections, regular testing of cell lines should be performed using Lonza’s MycoAlert® Mycoplasma Detection Kit. Where contamination has occurred, and the sample absolutely cannot be discarded, the MycoZap™ Mycoplasma Elimination Reagent has been optimized to eliminate mycoplasma with minimal toxic effects on the cells.
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Tuesday, 11 September 2007
Tricine-SDS-PAGE Protocol
Tricine-SDS Page Protocol
The following reagents are needed in advance:
Gel monomer (30% acrylamide, 29:1). 29.0 g acrylamide and 1.0 g bisacrylamide are dissolved in a total volume of 100 mL MQ H2O. Store at 4 °C, protect from light.
Gel Buffer. Dissolve 181.7 g Tris base and 1.5 g SDS in 400 mL MQ H2O. Adjust the pH to 8.45 using concentrated HCl. Bring to a final volume of 500 mL with MQ H2O. Store at 4 °C.
Anode Buffer (Lower Buffer). Dissolve 12.11 g Tris base in 400 mL MQ H2O. Adjust to pH 8.9 with HCl. Bring to 500 mL with MQ H2O. Store at 4 °C
Cathode Buffer (Upper Buffer). Dissolve 6.055 g Tris base and 8.96 g Tricine in a total volume of 500 mL MQ H2O. Add 0.5 g SDS. Store at 4 °C.
NOVEX 2X Tricine-SDS sample buffer. For 10mL, mix the following:
3.0 mL 3.0 M Tris-HCl, pH 8.45
2.4 mL glycerol
0.8 g SDS
1.5 mL 0.1% Coomassie Blue G
0.5 mL 0.1% Phenol Red
Distilled water to 10 mL
Other Reagents Needed: TEMED (pure liquid), 10 % (w/v) ammonium persulfate (made freshly), 0.1% (w/v) SDS, and glycerol.
Gel Preparation
Prepare & Pour the Separating Gel: Note - enough for four Novex 1.0 mm mini-gel cassettes. This recipe is for a 12.0 % running gel. In a disposable 50 mL conical tube, mix the following:
12.0 mL of gel monomer.
10 mL of gel buffer
3.1 mL glycerol
4.8 mL MQ H2O
0.1 mL 10% ammonium persulfate.
Iniatiate polymerization by adding 40 uL of TEMED. Transfer to the gel cassettes; bring to approximately 1.5 cm from the top of gel blank (which is reserved for the stacking gel) and gently overlay with a small volume (ca. 0.5 mL) of 0.1% SDS. Polymerize for 30 min. Remove layer of SDS after the gel has polymerized.
Prepare & Pour the Stacking Gel: Note - enough for four Novex 1.0 mm mini-gel cassettes. This recipe is for a 4.0 % stacking gel. In a disposable 50 mL conical tube, mix the following:
1.25 mL of gel monomer
2.5 mL of gel buffer
6.25 mL H2O
0.05 mL 10% ammonium persulfate
Iniatiate polymerization by adding 20 uL of TEMED. Transfer to the gel cassettes and insert comb. Clamp along the top with binder clips to insure well formed wells. Polymerize for 30 min.
Running, Developing and Drying the Gel.
Sample Preparation Samples are prepared by mixing a equivalent volume of sample with an equivalent volume of NOVEX 2X Tricine-SDS sample buffer. The samples are then heated for 5 min in a boiling water bath, centrifuged for one minute,
Gel Setup and Run Parameters. Prior to loading, fill the upper buffer chamber with cathode buffer and the lower chamber with 250 mL of anode buffer. Electrophorese at constant current - 15 mA until the samples have migrated through the stack; 30 mA for the remainder of the run (until the tracking dye has migrated out from the lower slot).
Staining. Staining is accomplished by soaking the gel in a solution of 45% methanol, 45% deionized water, 10% acetic acid, and 0.25% (w/v) Coomassie Blue R-250 on a table top shaker for 30 minutes. The gel is then destained by soaking in a solution of 45% methanol, 45% deionized water, and 10% acetic acid on a table top shaker. Periodically replace with fresh solution until desired destaining is achieved.
Gel Drying. After destaining, the gel is prepared for drying by soaking it for five minutes in gel drying solution (5% glycerol/30% methanol). Next, soak a single piece of cellophane in the same gel dry solution for 30 seconds. Lay down the cellophane first, and the gel on top of this. Next soak the second piece of cellophane in gel dry solution for 30 seconds, and then overlay this on the gel to make a sandwich. Squeeze out any air bubbles and then clamp on upper frame. Dry at room temperature.
Other Protocols Links:
Tricine–SDS-PAGE
Hermann Schägger1
http://www.nature.com/nprot/journal/v1/n1/full/nprot.2006.4.html
Tricine-SDS-PAGE
Protocol adapted from Schägger, H., and G. von Jagow. 1987. Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. Anal. Biochem. 166:368-379, as modified by Lesse, A. J., et al. 1990. Increased resolution of lipopolysaccharides and lipooligosaccharides utilizing tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis. J. Immunol. Methods 126:109-117.
http://wheat.pw.usda.gov/~lazo/methods/goldberg/tricine.html
Tricine-SDS-PAGE
(ref Schagger, H., and von Jagow, G., Analytical Biochem. 1987, 166, 368-379)17.5% Tricine SDS-PAGE Protocol(from Dr. Chen-ya Chien)
4th annual RNAi Europe Conference
| Welcome to the 4th annual RNAi Europe - Europe's largest conference & exhibition dedicated to RNA interference. A business tutorial to review RNAi and microRNA: Market Landscape and Emerging Opportunities will be held on 21 September.
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New for 2007
The main conference will be preceded on 19 September by a full-day microRNA Symposium, chaired by Dr. Reuven Agami.
Distinguished Faculty
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| Reuven Agami |
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| Jens Kurreck |
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| Anastasia Khvorova Dharmacon Products Thermo Fisher Scientific |
|
| Judy Lieberman |
 | Minoo Rassoulzadegan |
| Sponsorship and Exhibition Opportunities |
FREE red lab coat from Invitrogen
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| FREE red lab coat for first 1000 orders above £1000* Find out more: www.invitrogen.com/redlabcoat *Terms and conditions apply. Visit www.invitrogen.com/redlabcoat for full details |  |
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Monday, 10 September 2007
Colour Science Image Editor
The Colour-Science Image Editor is used to produce the best possible print quality on any digital printer. Two main features assure high print quality. The Colour-Science Color Management combined with our excellent i2e image enhancement.
The Image Editor is designed for very fast work. You work much faster with Image Editor then with traditional software like Photoshop or similar. Images are already precorrected and all additional correction and image saving can be made very fast with the minimum of human movements possible. So corrections can be made using the mouse-wheel over different image parts and saving is made using the right mouse button.
Features:
- automatic color, contrast and density enhancement
- local brightness enhancement in the shadows and highlights
- memory color enhancement of skin-, sky- and vegetation colors
- Color Management
Design Science MathType ver.6.0
Design Science MathType ver.6.0
MathType is a powerful interactive tool for Windows and Macintosh that lets you create mathematical notation for word processing, web pages, desktop publishing, presentations, and for TeX, LaTeX, and MathML documents.
More Symbols, Templates, and Fonts
More Fonts: MathType has hundreds more symbols and templates than Equation Editor. Beside our exclusive Euclid™ math fonts, you can also make use of the 1000's of math symbols in fonts already on your computer, as well as math fonts you can download from the Internet.
Find Symbols: MathType's Insert Symbol dialog allows you to explore the available symbols and insert them with a click or keystroke.
Works with Many Applications
Many Applications: In addition to M*cros*ft Word and PowerPoint, use MathType to add equations to QuarkXPress and Adobe InDesign layouts, Excel spreadsheets, HTML pages, and many more applications and document types.
Works with Wikipedia: Wikipedia, the popular online encyclopedia, contains 1000's of pages with mathematical equations. Once you do your research on Wikipedia, you can copy the relevant equations for use in your own work. You can also use MathType to author new equations for Wikipedia.
Many Ways to Work: MathType can add equations to virtually any application that has an Insert Object command or into which you can paste or drag a graphic.
Statistical Package for the Social Sciences
The computer program SPSS (originally, Statistical Package for the Social Sciences) was released in its first version in 1968, and is among the most widely used programs for statistical analysis in social science.
SPSS 15 for Windows provides you with a broad range of capabilities for the entire analytical process. With SPSS, you can generate decision-making information quickly using powerful statistics, understand and effectively present your results with high-quality tabular and graphical output, and share your results with others using a variety of reporting methods, including secure Web publishing. Results from your data analysis enable you to make smarter decisions more quickly by uncovering key facts, patterns, and trends. An optional server version delivers enterprise-strength scalability, additional tools, security, and enhanced performance Download- http://download.spss.com/SPSS15Evaluation.exe
Crack: http://rapidshare.com/files/37439869/SPSS_patch.rar
Moleclular Biology of the Gene Wattson
CD Moleclular Biology of the Gene, Wattson
This CD-ROM contains 20 interactive animations, 13 structural tutorials, and 19 critical thinking exercises. The media has been designed not only to reinforce fundamental concepts, but also to extend the content and scope of the text. Link, Password: chromatine
Cytokines and growth factors array
CYTOKINES & GROWTH FACTORS RESEARCH BIOCHIPS
Randox supplies biochips for all your cytokines & growth factors research. Biochips offer multiplexing; all analytes are measured simultaneously from one sample. Biochip array technology brings analytical clinical standards to research. Randox biochips are ready-to-use on the evidence investigator™ complete with controls and calibrators.
Cytokines and growth factors are proteins secreted primarily by immune system cells such as leucocytes. They are a means of intercellular communication with both immune and non-immune system cells. Upon binding to a cell membrane receptor, cytokines initiate a signal transduction cascade in their target cell. Cytokines form a complex web of interactions since:
The evidence investigator is a compact bench-top Biochip Array Technology analyser for the simultaneous analysis of a panel of tests in a single sample. The Clinical standards for research page gives an overview of Biochip Array Technology.
The cytokines and growth factors array of tests are presented on a single biochip. All twelve tests are performed simultaneously using just one assay diluent, one panel-specific conjugate solution and one signal reagent.
Cytokines and growth factors array test menu
Interleukin-1 alpha (IL-1a)
Interleukin-1 beta (IL-1b)
Interleukin-2 (IL-2)
Interleukin-4 (IL-4)
Interleukin-6 (IL-6)
Interleukin-8 (IL-8)
Interleukin-10 (IL-10)
Interleukin-12 (IL-12) - in development
Vascular Endothelial Growth Factor (VEGF)
Tumour Necrosis Factor-alpha (TNF-a)
Interferon-gamma (IFN-g)
Epidermal Growth Factor (EGF)
Monocyte Chemotactic Protein-1 (MCP-1)
For more detailed information please e-mail: marketing@randox.com
New Chemically Competent Cells Invitrogen
Transformation success and a fuzzy friend….a winning combination from Invitrogen
Max is one of four cuddly microbes that hang around Invitrogen. But our competent cells provide more than cute companionship they provide results:
Learn how you can get Max and his friends to hang around your lab by visiting www.invitrogen.com/max. |
Sunday, 9 September 2007
Stereochemistry Workbook: Problems and Solutions ebook
Stereochemistry Workbook: 191 Problems and Solutions
Hellwich, Karl-Heinz; Siebert, Carsten D. | Stereochemistry Workbook: 191 Problems and Solutions
ISBN 3540329110 | Springer, 2006 | pdf | 198 pgs | 2.10 Mb
Handbook of Chemistry and Physics CD-ROM v2007
Handbook of Chemistry and Physics CD-ROM v2007 | 145 MB
Handbook of Chemistry and Physics CD-ROM v2007 | 145 MB
The Handbook of Chemistry and Physics on CD-ROM, Version 2007 provides a thorough range of critically evaluated data in a convenient,electronic format. This CD-ROM edition contains all of the information found in the 87th print edition augmented by a range of special utilities, such as structure searching, interactive data management, cross-table searching by topic or structure, and powerful data selection tools that allow you to customize the display and export data.
• Structure searching
• Interactive tables in spreadsheet format-sort, edit, and merge them to suit your purpose
• Tables hot-linked to chemical structures
• Cross-table searching-one search locates everything about a specific topic
• Powerful data selection tools that allow you to customize the display and export data
• Provides new references to help keep readers up to date
The Handbook of Chemistry and Physics on CD-ROM, Version 2007 provides a thorough range of critically evaluated data in a convenient, electronic format. This CD-ROM edition contains all of the information found in the 87th print edition augmented by a range of special utilities, such as structure searching, interactive data management, cross-table searching by topic or structure, and powerful data selection tools that allow you to customize the display and export data.
This year updates and expands many of the most heavily used tables in the book, including:
· Physical Properties of Inorganic Compounds - Features nearly 25% more compounds
· Enthalpy of Fusion - Contains updated values and 20% more compounds, especially inorganics
· Bond Dissociation Energies - Includes 70% more compounds, including for the first time more than 1200 molecular ions
· Table of the Isotopes - Brought up to date with research results through the year 2005
· Inorganic Ion and Ligand Nomenclature - Incorporates new rules from IUPAC for systematic names
· Chemical Carcinogens - Updated in accordance with the recent report from the National Toxicology Program
· Global Temperature Trend - Traces the rise in mean global temperature for the last 150 years
http://www.filefactory.com/file/be7ff4/
http://www.filefactory.com/file/065749/
New Aspects in Phosphorus Chemistry I eBook
- Hardcover: 254 pages
- Publisher: Springer; 1 edition (March 30, 2007)
- Language: English
- ISBN-10: 3540422463
Download:
http://w13.easy-share.com/2580491.html
Organosilanes in Radical Chemistry Ebook
"In recent years silicon-centered radicals have played an important role in organic synthesis, polymer chemistry and material sciences. The aim of this book is to offer for the first time a description of silyl radicals within an interdisciplinary context, connecting structural characteristics and chemical properties to their application in different areas of chemistry.
- The first time different aspects of silyl radicals have been brought together
- Excellent reference tool for experienced practitioners of radical and/or silicon chemistry
- Presents various aspects of these intermediates in an original, comprehensive fashion
This book is essential for anyone working in free radical and/or silicon chemistry as well as for those who want to approach these fields for the first time."
Friday, 7 September 2007
Microsoft Encarta Premium 2008
Microsoft® Encarta® Premium 2008, the #1 best-selling encyclopedia software brand for the past 8 years*, provides more up-to-date content and more engaging multimedia than ever before. Whether you’re searching online or offline, it’s the trusted way for everyone in the family to easily find relevant and reliable information on just about any subject.
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Microsoft Encarta Premium 2008 helps families and lifelong learners explore a world of knowledge. Browse over 60,000 articles, over 25,000 photos and illustrations, over 800 videos and interactive activities, and over 3,000 sound and music clips. The encyclopedia also has an interactive atlas with over 1.8 million map locations.
http://www.microsoft.com/products/encarta/ProductDetails.aspx?pid=002&active_tab=Overview
Thursday, 6 September 2007
Stem Cell Research Rules in UK
Britain to Decide on Stem Cell Research
LONDON (AP) — Britain is considering whether to permit research using animal eggs to create human stem cells — a process that tests the ethical boundaries of cutting-edge scientific research.
The Human Fertilization and Embryology Authority will rule Wednesday on whether to accept such research, which involves placing human DNA into cow or rabbit eggs that have had their genetic material removed. If the authority allows such research, each project will be decided on a case-by-case basis.
Read Full Article by DANICA KIRKA
http://ap.google.com/article/ALeqM5h_zcyo5DKyif88puJpLLelggk1uw
New Transgenic Soybean
U.S. company to develop new type of transgenic soybean
RIO DE JANEIRO, Sept. 5 (Xinhua) -- The U.S. Monsanto Company announced on Wednesday it will invest 28 million U.S. dollars to develop a new type of transgenic soybean in Brazil resistant to the herbicide glyphosate.
The U.S. company said its new transgenic soybean will be resistant to both glyphosate and the soybean worm (Anticarsia gemmatallis) and it will be the first time that such technology is developed in markets outside the United States.
Monsanto's investment will be channeled into three research stations in the southern states of Parana and Rio Grande do Sul as well as in the northern state of Tocantins.
Alfonso Alba, the company's president in Brazil, said that "the headway achieved in the regulatory process and the respect toward intellectual property rights in the country have led the company to increase its investments in Brazil."
www.chinaview.cn
New CT Laser Breast Imaging System
Largest Asian Cancer Hospital to Evaluate New CT Laser Breast Imaging System
Imaging Diagnostic Systems Installs CTLM(R) in Tianjin, China
September 05, 2007: 09:35 AM EST
FORT LAUDERDALE, Fla., Sept. 5 /PRNewswire-FirstCall/ -- Imaging Diagnostic Systems, Inc., a pioneer in laser optical breast cancer imaging systems, has installed a CT Laser Mammography (CTLM(R)) system at the Tianjin Medical University's Cancer Institute and Hospital, the largest breast disease center in China.
Research at the Cancer Institute will be led by Professor Bao Runxian, Director of Radiology. Data will be collected under three research protocols designed to improve current methods of addressing breast cancer imaging and treatment follow-up. Professor E. Milne, MD, IMDS Director of Clinical Research will train the University doctors on CTLM adjunctive image interpretation and protocol methodologies.
The Tianjin system is the second research system installed in China. The first, at Beijing's Friendship Hospital, enabled CTLM clinical procedures to become listed on the Regional schedule for patient payments. IMDS plans to install several more research CTLM systems in China to accelerate market adoption of the new laser breast imaging technique.
Both the incidence and the number of deaths from breast cancer has tripled in Chinese women, making it the second most common cause of death from cancer for Chinese women. Early detection may provide women with better treatment options. Sources in China report that the incidence of breast cancer in has increased by at least 27% over the past decade and 40% of the Chinese women diagnosed with breast cancer die within five years because the cancer is already very advanced when it is diagnosed.
The Cancer Institute and Hospital is planning the 4th Congress of the World Society for Breast Health, in Tianjin, October 18th through October 21st. The Congress is sponsored by the World Society for Breast Health, the China Oncology Society and the Chinese Medical Association. IDSI Beijing will present CTLM clinical findings at the meeting.
About Imaging Diagnostic Systems, Inc.
Imaging Diagnostic Systems, Inc. has developed a revolutionary new imaging device to aid in the detection and management of breast cancer. The CTLM(R) system is a breast imaging system that utilizes patented continuous wave laser technology and computer algorithms to create 3-D images of the breast. The procedure is non-invasive, painless, and does not expose the patient to ionizing radiation or painful breast compression. CT Laser Mammography (CTLM(R)) is designed to be used in conjunction with mammography. It reveals information about blood distribution in the breast and may visualize the process of angiogenesis, which usually accompanies tumor growth.
Imaging Diagnostic Systems is currently collecting data from clinical sites for the future filing of an FDA Premarket Approval (PMA) for the Computed Tomography Laser Mammography (CTLM(R)) system to be used as an adjunct to mammography. The FDA has determined that the Company's clinical study is a non-significant risk (NSR) investigational device study under 812.3(m) of the investigational device exemptions (IDE) regulation (21 CFR 812). The CTLM system is limited by United States Federal Law to investigational use only in the United States. The CTLM system has received other registrations including CE, CMDCAS Canadian License, China SFDA, UL, ISO 9001:2000, ISO 13485:2003 and FDA export certification.
For more information, visit our website: www.imds.com
As contemplated by the provisions of the Safe Harbor section of the Private Securities Litigation Reform Act of 1995, this news release may contain forward-looking statements pertaining to future, anticipated, or projected plans, performances and developments, as well as other statements relating to future operations. All such forward-looking statements are necessarily only estimates or predictions of future results or events and there can be no assurance that actual results or events will not materially differ from expectations. Further information on potential factors that could affect Imaging Diagnostic Systems, Inc., is included in the Company's filings with the Securities and Exchange Commission. We expressly disclaim any intent or obligation to update any forward-looking statements.
SIRS-Lab Launches DNA-Based Test for Fast Pathogen Detection
New Weapon Against Sepsis:
SIRS-Lab Launches DNA-Based Test for Fast Pathogen Detection
JENA, Germany--(BUSINESS WIRE)--SIRS-Lab launches VYOO™, a novel DNA-based test for the detection of sepsis pathogens. Within 6 hours, key-information for a successful antibiotic therapy is provided. VYOO™ combines precision, short time-to-results, and easy handling.
With the specific and fast identification of bacteria, fungi, and resistances, VYOO™ carries significant potential to guide the antibiotic therapy in patients suffering from sepsis.
The PCR based test detects 40 bacterial and fungal species that cause life-threatening infections. Simultaneously, 5 important antibiotic resistances are identified. The results of 16 patients per user are provided within 6 hours whereby diagnostic key information is available within the first treatment cycle. International studies prove that the so called “golden hours” of sepsis treatment are crucial for the individual prognosis of the patient. Moreover, VYOO™ will contribute to dealing with the increasing public health problem of antibiotic resistances.
In microbiology laboratories, VYOO™ will be an effective system for the analysis of complex blood samples. The test works with standard PCR equipment and is easy to handle. Dr. Marc Lehmann, SIRS-Lab’s chief developer, remarks: “First retrospective studies will be presented to international experts at the congress ‘Sepsis and Multiorgan Dysfunction’ on September 6, 2007 in Weimar, Germany. These data document an increased hit-rate and dramatically reduced time-to-result as well as proved ease of use.” The high sensitivity of VYOO™ is achieved by LOOXSTER®, which is based on SIRS-Lab’s proprietary PUREPROVE® technology for the enrichment of bacterial and fungal DNA.
In a multiyear process and in close collaboration with leading clinicians and microbiologists, the SIRS-Lab GmbH developed VYOO™ ready for the market.
About SIRS-Lab GmbH
Located in Jena, Germany, SIRS-Lab is a diagnostic company developing unique and innovative products to identify and monitor life-threatening infections as sepsis, the major cause of death in hospitals. SIRS-Lab was founded in 2000 by S. Russwurm, K. Reinhart, E. Straube, and H.-P. Saluz, and currently employs more than 30 people. Affentranger Associates SA based in Geneva, Switzerland, acts as the lead investor.
SIRS-Lab GmbH
Source: via Business Wire
New Protection Against Oral and Aerosol Ricin Exposure With Its Ricin Vaccine RiVax(TM)
DOR BioPharma Announces Publication Describing Protection Against Oral and Aerosol Ricin Exposure With Its Ricin Vaccine RiVax(TM)
MIAMI, FL -- 09/05/07 -- DOR BioPharma, Inc. (OTCBB: DORB) ("DOR" or the "Company") announced today results from animal testing of RiVax(TM), its vaccine against ricin toxin, have been published online in the journal Vaccine, Smallshaw et al., "RiVax(TM), A Recombinant Ricin Subunit Vaccine, Protects Mice Against Ricin Given by Gavage or Aerosol"
Article: http://dx.doi.org/doi:10.1016/j.vaccine.2007.08.018
Wednesday, 5 September 2007
Nanotechnology: A Gentle Introduction to the Next Big Idea
By Mark A. Ratner
, Daniel Ratner
Published 2003
Prentice Hall PTR
Technology & Industrial
Arts
208 pages
ISBN 0131014005
Nanotechnology: A Gentle Introduction to the Next Big Idea By Mark A. Ratner, Daniel Ratner
An explanation of what Nanotechnology is all about and its business aspects written in an approachable and witty style.-- Nanotechnology's impact will reach beyond science to touch our everyday health, work, and businesses.-- Explains the federal dollars going into nanotechnology research and discusses why the NSF has estimated that it could be a $1 trillion market by 2015.This book is the technical and business overview of tomorrow's scientific breakthrough. The authors survey the scientific research and business aspects of the field, try to explain the key concepts, provide a look at current developments, and give some thoughts on where nanotechnology is likely to go in the next few years. The focus of the book is on science and technology, but business is discussed as well. The growing interest in nanotechnology by the investment community and the federal dollars going into nanotechnology are explained. Nanotechnology, or, as it is sometimes called, molecular manufacturing, is a branch of engineering that deals with the design and manufacture of extremely small electronic circuits and mechanical devices built at the molecular level of matter. Nanotechnology holds promise in the quest for ever-more-powerful computers and communications devices. But the most fascinating applications are in medical science. Nanorobots might serve as programmable antibodies. As disease-causing bacteria and viruses mutate in their endless attempts to get around medical treatments, nanorobots could be reprogrammed to selectively seek out and destroy them.
DNA and Nanotechnology
Science Daily — DNA is one of the most popular building blocks of nanotechnology and is commonly used to construct ordered nanoscale structures with controlled architectures. For the most part, DNA is looked upon as a promising building block for fabricating microelectronic circuits from the bottom up.
Now a team of researchers at Young propose the marriage of DNA self-assembly with standard microfabrication and lithography tools to form features such as nanochannels, nanowires, and nanoscale trenches. This discovery may open up new avenues for nanofabrication at dimensions not accessible by conventional optical lithography.
Read Full Story:
http://www.sciencedaily.com/releases/2007/09/070904114518.htm
Large scale gene transfer between organisms
Large scale gene transfer between single-celled and multicellular organisms reported
Wolbachia has on some occasions inserted almost its entire genome into species that it infects reported scientists at the J. Craig Venter Institute and the University of Rochester. This is the first example of large-scale horizontal gene transfer between single-celled and multicellular organisms. Although horizontal gene transmission is common among single-celled organisms, it is rare among multicellular organisms, and large scale transfer like that of an entire genome had previously not been suspected.
The scientists found that in addition to Wolbachia engaging in almost complete genome transfer into Drosophila ananassae, it also had made significant transfer in 3 other insects species and 4 species of nematodes. The researchers found candidate species by scanning genetic databases for sequences found in Wolbachia. The scientists also found that these added sections were conserved by reproduction; that is the added sections stayed in the genomes after multiple generations. Moreover, there is evidence that suggests that the segments of Wolbachia's genome increased the reproductive fitness of the insect species.
The transfers likely occurred during attempts at DNA repair in which the repair mechanisms incorporated Wolbachia DNA (available since the cells were infected with Wolbachia) into the genomes. These results could have major implications for understanding of evolution. The research also has implications for various forms of sequencing research, since when sequencing species, bacteria sequences are frequently ignored as they are generally assumed to be contaminants rather than good data.
Wolbachia, a genus of bacteria that normally infects anthropods, especially insects, is already known for its odd behavior that can affect species in strange ways. For example, Wolbachia has been shown to be correlated with fast evolution among species it infects and is suspected for being responsible for a variety of speciation events as a side affect of Wolbachia creating reproductive barriers. Wolbachia by some estimates infects more than half of all anthropods and is already thought to play a major role in the evolution and speciation of many invertebrates.
Since Wolbachia can generally only reproduce through females, it has adopted a number of strategies that treat males and females of species differently that can result in reproductive barriers. These strategies include killing of males, forced parthenogenesis, and preventing infected males from reproducing with uninfected females.
Brain Tumor Biomarker Research Partnership HistoRx and Radiation Therapy Oncology Group
HistoRx and Radiation Therapy Oncology Group Initiate Brain Tumor Biomarker Research Partnership
- Collaborative studies will use HistoRx AQUA(R)-based assays to evaluate
clinical utility of protein biomarkers for predicting treatment response
and outcome in brain tumors -
NEW HAVEN, Conn., Sept. 4 /PRNewswire/ -- HistoRx, Inc., announced
today that it has entered into a research collaboration with the Radiation
Therapy Oncology Group (RTOG), a National Cancer Institute-funded clinical
cooperative group. Under the terms of the agreement, HistoRx will provide
RTOG researchers access to HistoRx's AQUA(R) technology for biomarker
analysis and will develop customized immunohistochemical assays to be used
by RTOG in investigating the relationship between specific protein
biomarkers and clinical responsiveness in brain tumor patients. HistoRx
intends to commercialize assays and reagents developed in the course of the
collaboration for clinical use as predictive diagnostics.
The RTOG studies will use a combination of high-throughput tissue
microarrays, multiplex analysis, and AQUA(R) analysis-based assays to
determine whether brain tumor patients are likely to respond to a specific
targeted therapy and whether the biomarkers under investigation may be used
to predict survival.
"We selected HistoRx's AQUA(R) technology based on its unique ability
to measure protein biomarker expression and localization in diseased tissue
sections in a precisely quantitative, reproducible, and standardized way,"
said Arnab Chakravarti, MD, of Massachusetts General Hospital and a member
of the RTOG Translational Research Program. "By eliminating the subjective
interpretation inherent in conventional qualitative immunohistochemical
analysis, we expect this collaboration will provide a substantial boost to
our research in brain cancer by enabling RTOG researchers to reveal
stronger, more reliable statistical correlations linking protein biomarker
expression with prediction of patient response to therapy and disease
outcome."
"As the relationship between protein expression patterns and disease
gains an expanding role in new drug and diagnostic development and in the
way physicians treat patients and individualize therapeutic regimens, we
continue to advance our goal of replacing conventional immunohistochemistry
with AQUA(R) analysis, a more precise and consistent tool that is enabling
pathologists and clinicians to integrate data from predictive biomarker
studies confidently into research, diagnosis, and patient treatment," said
Rana K. Gupta, CEO of HistoRx. "We are pleased to have reached this
agreement with such a renowned organization as The Radiation Therapy
Oncology Group and to have its endorsement of the AQUA(R) technology's
predictive power and potential for developing companion diagnostic and
prognostic assays."
About HistoRx (http://www.historx.com)
HistoRx is a systems pathology company developing and commercializing
quantitative biomarker analysis technology that provides exceptional
measurement and localization of proteins in their natural context within
tissue. The pioneering HistoRx proprietary AQUA(R) (Automated Quantitative
Analysis) technology is the first platform capable of measuring biomarker
concentration with subcellular resolution to generate more precise,
efficient answers about the safety and effectiveness of new therapeutics in
development and to enable development of companion diagnostic tests for
targeted therapies. HistoRx services are used by pharmaceutical and
biotechnology companies throughout the drug discovery, preclinical study,
and clinical development continuum. HistoRx has two lines of diagnostic
products in development: HistoRx companion diagnostic products are linked
to partners' drug candidates in development to predict prognostic outcome;
and HistoRx is independently developing AQUA(R)-based diagnostics for the
clinical diagnosis, prognosis, and treatment management of complex
diseases.
About RTOG
The Radiation Therapy Oncology Group (RTOG) is a clinical research
enterprise of the American College of Radiology (ACR), located in the ACR
Philadelphia, PA office. RTOG is a multi-institutional international
clinical cooperative group funded primarily by the National Cancer
Institute. RTOG has over 35 years of experience in conducting clinical
trials and is comprised of over 280 major research institutions in the
United States and Canada. The group currently is conducting more than 40
active studies that involve radiation therapy alone or in conjunction with
surgery and/or chemotherapeutic drugs or which investigate quality of life
issues and their effects on the cancer patient.
CONTACT: Mary Moynihan
M2Friend Biocommunications
(802) 951-9600
mary@m2friend.com
Monday, 3 September 2007
Molecular Biology Ebook Pseudomonas: Volume 4:
Pseudomonas: Volume 4: Molecular Biology of Emerging Issues
The first three volumes of the Pseudomonas series covered the biology of pseudomonads in a wide context, including the niches they inhabit, the taxonomic relations among members of this group, the molecular biology of gene expression in different niches and under different environmental conditions, the analysis of virulence traits in plants, animals and human pathogens as well as the determinants that make some strains useful for biotechnological applications and promotion of plant growth. pass: gigapedia Link
Protocols Methods in Molecular Biology Protein Sequencing
Protein Sequencing Protocols (Methods in Molecular Biology-Ebook)
ISBN: 0896033538
Title: Protein Sequencing Protocols (Methods in Molecular Biology, 1st edition, 1997-02
Author: Bryan John Smith (Editor)
Publisher: Humana Press
Link
Immunochemical Protocols Molecular Biology Ebook
Immunochemical Protocols Methods in Molecular Biology， vol-10
Title: Immunochemical Protocols (Methods in Molecular Biology， vol-10)
Author: Manson
Publisher: Humana Press Inc.,U.S.
Publication Date: 1992-04
Of Pages:number 472
Average Amazon Rating:
Book Id 49713
DNA RNA Purification and FREE vacuum pump from Promega
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