Cytokines and growth factors array

CYTOKINES & GROWTH FACTORS RESEARCH BIOCHIPS

Randox supplies biochips for all your cytokines & growth factors research. Biochips offer multiplexing; all analytes are measured simultaneously from one sample. Biochip array technology brings analytical clinical standards to research. Randox biochips are ready-to-use on the evidence investigator™ complete with controls and calibrators.

Cytokines and growth factors are proteins secreted primarily by immune system cells such as leucocytes. They are a means of intercellular communication with both immune and non-immune system cells. Upon binding to a cell membrane receptor, cytokines initiate a signal transduction cascade in their target cell. Cytokines form a complex web of interactions since:

Different cytokines can have similar effects.

Cells interact with a variety of cytokines.

Cytokines may affect the activity and expression of other cytokines.

evidence investigator
The evidence investigator is a compact bench-top Biochip Array Technology analyser for the simultaneous analysis of a panel of tests in a single sample. The Clinical standards for research page gives an overview of Biochip Array Technology.
The cytokines and growth factors array of tests are presented on a single biochip. All twelve tests are performed simultaneously using just one assay diluent, one panel-specific conjugate solution and one signal reagent.
Cytokines and growth factors array test menu
Interleukin-1 alpha (IL-1a)
Interleukin-1 beta (IL-1b)
Interleukin-2 (IL-2)
Interleukin-4 (IL-4)
Interleukin-6 (IL-6)
Interleukin-8 (IL-8)
Interleukin-10 (IL-10)
Interleukin-12 (IL-12) - in development
Vascular Endothelial Growth Factor (VEGF)
Tumour Necrosis Factor-alpha (TNF-a)
Interferon-gamma (IFN-g)
Epidermal Growth Factor (EGF)
Monocyte Chemotactic Protein-1 (MCP-1)
For more detailed information please e-mail: marketing@randox.com

Details: CYTOKINES & GROWTH FACTORS RESEARCH BIOCHIPS

ENCODE-Encyclopedia Of DNA Elements

ENCODE= the Encyclopedia Of DNA Elements

ENCODE was started in September 2003 to identify all functional elements in the human genome sequence by the National Human Genome Research Institute (NHGRI).

Project has three phases.

1. a pilot project phase-testing and comparing existing methods to rigorously analyze a defined portion of the human genome sequence

2. a technology development
3. a planned production phase

Full details can be found at http://www.genome.gov/10005107

This week Nature published the results of the pilot phase of ENCODE project.


Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project
The ENCODE Project Consortium*
http://www.nature.com/nature/journal/v447/n7146/pdf/nature05874.pdf

One of the main conclusions they are pointing to is that there is a lot of places wherethere appears to be conservation of function (transcription and it's regulation) without conservation of sequence. Very interesting.. but long way to go.