Isolation of Acetylsalicylic Acid from Aspirin Tablets

Here we have compiled a list of laboratory protocols from various colleges and universities for the Isolation of acetylsalicylic acid from aspirin tablets.

Isolation of acetylsalicylic acid from aspirin tablets

Organic Chemistry Laboratory CHE 327 

Cornell College Term 7, 2004/2005

Addison Ault, Andrea Pionek, Mary Anne Teague, Charley Liberko

http://people.cornellcollege.edu/cliberko/OrgLabManual.htm


Organic Chemistry Laboratory
Isolation of Acetysalicylic Acid from Aspirin Tablets


Aspirin, like most tablets, contains the active ingredient (acetylsalicylic acid) plus a binder to give the tablet its shape.  The active ingredient in aspirin will be recovered by recrystallization from ethanol.  The aspirin tablets you will be using contain 325 mg of acetylsalicylic acid per tablet.  (However, check the bottle to be certain, as occasionally substitutions have to be made.)

From Mansfield.edu [PDF]


Synthesis of Acetylsalicylic Acid (Aspirin)


Introduction: The purpose of this experiment is to synthesize acetylsalicylic acid via an esterification
reaction between salicylic acid and acetic anhydride.  The product will be recrystallized using
95% ethanol. The product will then be analyzed via infrared spectroscopy, nuclear magnetic
resonance spectroscopy, ultraviolet light visible spectroscopy, and melting point analysis. It
will then be compared with the IR, NMR, and UV spectra and melting point of acetylsalicylic
acid isolated from commercial aspirin
http://www.franklincollege.edu/pwp/lmonroe/Organic%20Chem/Aspirin.pdf